Gender Difference in Cisplatin-Induced Nephrotoxicity in a Rat Model
نویسنده
چکیده
BACKGROUND Nephrotoxicity and hepatotoxicity are side effects of Cisplatin (CP) therapy. OBJECTIVES We investigated the role of gender in CP-induced nephrotoxicity and hepatotoxicity. MATERIALS AND METHODS Low dose of CP (1 mg/kg/day; ip) was administered daily to male and female Wistar rats for 15 consecutive days. Serum creatinine (Cr), blood urea nitrogen (BUN), malondialdehyde (MDA), nitric oxide (NO) metabolite, and magnesium (Mg) levels were determined. RESULTS The percentage of weight loss and the serum levels of MDA and nitrite in male and female animals were not statistically different. However, the serum levels of BUN, Cr, Mg, and kidney MDA levels, and kidney weight and damage score were significantly greater in males than in females (P < 0.05). CONCLUSIONS CP-induced nephrotoxicity is gender related for which the mechanisms should be determined.
منابع مشابه
Effect of Glutathione on Cisplatin-Induced Nephrotoxicity in Male and Female Rats
SUMMARY Cisplatin is a widely used anticancer agents that is effective against ovarian and other tumors. This drug is recognized as nephrotoxic in human and experimental animals. The effect of cisplatin-induced kidney injury was predominantly investigated in male animals. This study was designed to assess effects of cisplatin on male and female rat kidneys. We also investigated the effect of g...
متن کاملCisplatin therapy and the problem of gender-related nephrotoxicity
*Corresponding author: Prof. Hamid Nasri, Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran. E-mail: [email protected] It is established that cisplatin therapy is accompanied by damage to the kidneys (1). However, cisplatin is an applicable antineoplastic agent, against solid tumors in clinic (1,2). Cisplatin or cis-diamminedichlorop...
متن کاملHydrogen sulfide ameliorates the kidney dysfunction and damage in cisplatin-induced nephrotoxicity in rat
Hydrogen Sulfide (H2S) prevents and treats a variety of disorders via its cytoprotective effects. However, the effects of H2S on rats with cisplatin (CP) nephrotoxicity are unclear. The aim was to study the effects of H2S on rats with CP nephrotoxicity. Thirty male Sprague-Dawley rats were divided into three groups: control group, nephrotoxic group received sing...
متن کاملThe Effect of Hydration Therapy with and without Magnesium Sulfate on Prevention of Cisplatin-Induced Nephrotoxicity
Background: Cisplatin is an antineoplastic agent used to treat many malignancies; however, the main side effect of cisplatin is nephrotoxicity. The aim of this study was to evaluate the effect of hydration therapy with and without magnesium on prevention of cisplatin-induced nephrotoxicity. Methods: This retrospective study was performed on 46 patients with malignancy who were candidate to rec...
متن کاملThe effects of vitamin E and selenium on cisplatin-induced nephrotoxicity in cancer patients treated with cisplatin-based chemotherapy: A randomized, placebo-controlled study
| July 2013 | 625 study on rat model of CP nephrotoxicity and observed, losartan may prevent CIN in males, but it promotes the CP‐induced damage in females, which may be related to the renin‐angiotensin system receptors in the kidneys.[7] Additionally, we recently reported that, vitamin E, vitamin C, or losartan is not nephroprotectant against CIN in presence of estrogen in ovariectomized rat m...
متن کامل